機能性食品素材・アグロバイオ研究部門プロジェクト

代表的な大型プロジェクト

  1. 文部科学省 バイオプロダクション次世代農工連携拠点(2008-2018年度)(研究担当者:金丸研吾准教授,芦田 均教授,大澤 朗教授)

アグロバイオ研究グループ

  1. Ohno, R., Teramura, H., Ogino, C., Kondo, A., Takumi, S. (2018) Genotypic effects on sugar and by-products of liquid hydrolysates and on saccharification of acid-insoluble residues from wheat straw. (2018) Genes Genet Syst., 93(1):1-7 https://doi.org/10.1266/ggs.17-00027
  2. Goda, T., Teramura, H., Suehiro, M., Kanamaru, K., Kawaguchi, H., Ogino, C., Kondo, A., Yamasaki, M. (2016) Natural variation in the glucose content of dilute sulfuric acid-pretreated rice straw liquid hydrolysates: implications for bioethanol production. Biosci Biotechnol Biochem. 80(5):863-869. https://doi.org/10.1080/09168451.2015.1136882
  3. Sharma, SS., Yamamoto, K., Hamaji, K., Ohnishi, M., Anegawa, A., Sharma, S., Thakur, S., Kumar, V., Uemura, T., Nakano, A., Mimura, T. (2017) Cadmium-induced changes in vacuolar aspects of Arabidopsis thaliana. Plant Physiol Biochem. 114:29-37. https://doi.org/10.1016/j.plaphy.2017.02.017

機能性食品素材腸内動態研究グループ

  1. Sasaki, D., Sasaki, K., Ikuta, N., Yasuda, T., Fukuda, I., Kondo, A., and Osawa, R. (2018). Low amounts of dietary fibre increase in vitro production of short-chain fatty acids without changing human colonic microbiota structure. Scientific Reports, 8, Article number: 435
  2. Sasaki, K., Sasaki, D., Okai, N., Tanaka, K., Nomoto, R., Fukuda, I., Yoshida, K., Kondo, A., and Osawa, R. (2017). Taurine does not affect the composition, diversity, or metabolism of human colonic microbiota simulated in a single-batch fermentation system. PLOS ONE, https://doi.org/10.1371/journal.pone.0180991
  3. Kishimoto, M., Nomoto, R., Mizuno, M., and Osawa, R. (2017). An in vitro investigation of immunomodulatory properties of Lactobacillus plantarum and L. delbrueckii cells and their extracellular polysaccharides. Bioscience of Microbiota, Food and Health, 36(3): 101-110
  4. Takagi, R., Sasaki, K., Sasaki, D., Fukuda, I., Tanaka, K., Yoshida, K., Kondo, A., and Osawa, R. (2016) A single-batch fermentation system to simulate human colonic microbiota for high-throughput evaluation of prebiotics. PLOS ONE, https://doi.org/10.1371/journal.pone.0160533

機能性食品素材体内動態研究グループ

  1. Wang, L., Yamashita, Y., Komeda, S., Saito, A., Ashida,H. (2018) Absorption, metabolism, distribution and faecal excretion of B-type procyanidin oligomers in mice after a single oral administration of black soybean seed coat extract. Food Funct, 9, 5362-5370
  2. Mitani, T., Watanabe, S., Yoshioka, Y., Katayama, S., Nakamura, S., Ashida, H. (2017) Theobromine suppresses adipogenesis through enhancement of CCAATenhancer-binding protein β degradation by adenosine receptor A1. Biochim Biophys Acta - Mol Cell Res, 1864: 2438-2448
  3. Mitani, T., Yoshioka, Y., Furuyashiki, T., Yamashita, Y., Shirai, Y., Ashida, H. (2017) Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress. Free Rad Biol Med, 106: 355-367
  4. Yamashita, Y., Wang, L., Namba, F., Ito, C., Toda, T., Ashida, H. (2016) Procyanidin promotes translocation of glucose transporter 4 in muscle of mice through activation of insulin and AMPK signaling pathways. PLoS One, 11: e0161704.

総説

  1. 大澤 朗、「腸管モデルの開発で、科学的実験の土台をつくる」、Top Researchers (オンラインジャーナル)、株式会社経営共創基盤 (2019)
  2. 佐々木大介, 佐々木健吾, 近藤昭彦, 大澤 朗、総説、in vitro 培養システムによる食物繊維のヒト腸内細菌叢への影響評価、ルミナコイド研究  Vol.22 No.2, 63-73(2019)
  3. 大澤 朗 、総説、食品成分の機能性・安全性評価の新展開、ー 神戸大学腸管モデルの概要 ー、ソフト・ドリンク技術資料、No.184 1号、p. 1-14 (2018)
  4. 大澤 朗、消化管からみた健康・栄養、日本栄養・食糧学会監修、南久則・宮本賢一・山田耕路(編)、「第6章 腸内細菌と健康・栄養」 pp. 103~126、建帛社、東京 (2018)
  5. 大澤 朗、ヒト腸管モデルを利用した食品成分の機能性・安全性評価: 神戸大学の取り組み、日本乳酸菌学会誌 第27巻 No.2, pp. 93~100 (2016)